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Publications

Peer-Reviewed Research Publications

  1. Kotikam,* V.; Rozners,* E. Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3'-Homologated Nucleoside Amino Acids. Org. Lett. 2017, 19, 4122-4125.
  2. Mutisya, D.; Hardcastle, T.; Cheruiyot, S. K.; Pallan, P. S.; Kennedy, S. D.; Egli, M.; Kelley, M. L.; van Brabant Smith, A.; Rozners,* E. Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. Nucleic Acids Res. 2017, 45, 8142-8155.
  3. Hnedzko,* D.; McGee, D. W.; Karamitas, Y. A.; Rozners,* E. Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids. RNA 2017, 23, 58-69.
  4. Endoh, T.; Annoni, C.; Hnedzko, D.; Rozners, E.; Sugimoto,* N. Triplex-forming PNA modified with unnatural nucleobases: the role of protonation entropy in RNA binding. Phys. Chem. Chem. Phys. 2016, 18, 32002-32006.
  5. Hnedzko, D.; McGee, D. W.; Rozners,* E. Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye. Bioorg. Med. Chem. 2016, 24, 4199-4205.
  6. Cheruiyot, S. K.; Rozners,* E. Fluorescent 2-Aminopyridine Nucleobases for Triplex-Forming Peptide Nucleic Acids. ChemBioChem 2016, 17, 1558-1562.
  7. Anosova, I.; Kowal, E. A.; Sisco, N. J.; Sau, S.; Liao, J.-y.; Bala, S.; Rozners, E.; Egli, M.; Chaput, J. C.; Van Horn,* W. D. Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. ChemBioChem 2016, 17, 1705-1708.
  8. Annoni, C.; Endoh, T.; Hnedzko, D.; Rozners, E. Sugimoto,* N. Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing. Chem. Commun., 2016, 52, 7935-7938.
  9. Endoh, T.; Hnedzko, D.; Rozners, E.; Sugimoto,* N. Nucleobase-modified PNA suppresses translation by forming triple helix with a hairpin structure in mRNA in vitro and in cells. Angew. Chem., Int. Ed., 2016, 55, 899-903.
  10. Tse, J.; Wang, Y.; Zengeya, T.; Rozners, E.; Tan-Wilson,* A. Peptide nucleic acid probe for protein affinity purification based on biotin-streptavidin interaction and PNA-strand hybridization. Anal. Biochem. 2015, 470, 34-40.
  11. Mutisya, D.; Selvam, C.; Lunstad, B. D.; Pallan, P. S.; Haas, A.; Leake, D.; Egli,* M.; Rozners,* E. Amides Are Excellent Mimics of Phosphate Internucleoside Linkages and Are Well Tolerated in Short Interfering RNAs. Nucleic Acid Res. 2014, 42, 6542-6551.
  12. Tanui, P., Kennedy, S.D., Lunstad, B.D., Haas, A., Leake, D. and Rozners,* E. Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages. Org. Biomol. Chem. 2014, 12, 1207-1210.
  13. Zengeya,* T.; Gindin, A.; Rozners, E. Improvement of Sequence Selectivity in Triple Helical Recognition of RNA by Phenylalanine-Derived PNA. Artificial DNA: PNA & XNA 2013, 4, (3) 1-8 (Invited Manuscript).
  14. Muse, O.; Zengeya, T.; Mwaura, J.; Hnedzko, D.; McGee, D. W.; Grewer, C. T.; Rozners,* E. Conjugation of Peptide Nucleic Acid with Cationic Peptide Enhances Recognition of Double Helical RNA at Physiologically Relevant Conditions. ACS Chem. Biol. 2013, 8, 1683-1686.
  15. Walsh, J. M.; Ippoliti, P. J.; Ronayne, E. A.; Rozners, E.; Beuning,* P. J., Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily. DNA Repair 2013, 12, 713-722.
  16. Zengeya, T.; Gupta, P.; Rozners,* E. Triple Helical Recognition of RNA Using 2-Aminopyridine-Modified PNA at Physiologically Relevant Conditions. Angew. Chem., Int. Ed. 2012, 51, 12593-12596 (Very Important Paper).
  17. Patra, A.; Paolillo, M.; Charisse, K.; Manoharan, M.; Rozners,* E.; Egli,* M. 2'-Fluoro RNA Shows Increased Watson-Crick H-Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data. Angew. Chem., Int. Ed. 2012, 51, 11863-11866.
  18. Walsh, J. M.; Parasuram, R.; Rajput, P. R.; Rozners, E.; Ondrechen, M. J.; Beuning,* P. J., Effects of non-catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV). Environ. Mol. Mutagen. 2012, 53 (9), 766-776.
  19. Gupta, P.; Muse, O., Rozners,* E. Recognition of Double Stranded RNA by Guanidine-Modified Peptide Nucleic Acids (GPNA). Biochemistry, 2012, 51, 63-73.
  20. Gupta, P.; Zengeya, T., Rozners,* E. Triple Helical Recognition of Pyrimidine Inversions in Polypurine Tracts of RNA by Nucleobase-modified PNA Chem. Commun. 2011, 47, 11125-11127.
  21. Mutisya, D.; Selvam, C.; Kennedy, S. D.; Rozners,* E. Synthesis and properties of triazole-linked RNA. Bioorg. Med. Chem. Lett. 2011, 21, 3420-3422.
  22. Pallan, P.S.; Greene, E. M.; Jicman, P. A.; Pandey, R. K.; Manoharan, M.; Rozners,* E.; Egli,* M. Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA. Nucleic Acids Res. 2011, 39, 3482-3495.
  23. Zengeya, T.; Li, M.; Rozners,* E. PNA containing isocytidine nucleobase: synthesis and recognition of double helical RNA. Bioorg. Med. Chem. Lett. 2011, 21, 2121-2124.
  24. Selvam, C.; Thomas, S.; Abbott, J.; Kennedy, S. D.; Rozners,* E. Amides Are Excellent Mimics of Phosphate Linkages in RNA Angew. Chem. Int. Ed. 2011, 50, 2068-2070.
  25. Manoharan,* M.; Akinc, A.; Pandey, R. K.; Qin, J.; Hadwiger, P.; John, M.; Mills, K.; Charisse, K.; Maier, M. A.; Nechev, L.; Greene, E. M.; Pallan, P. S.; Rozners, E.; Rajeev, K. G.; Egli,* M. Unique Gene-silencing and Structural Properties of 2'-F Modified siRNAs. Angew. Chem. Int. Ed. 2011, 50, 2284-2288 (Featured as a Hot Paper chosen by the Editors).
  26. Li, M.; Zengeya, T.; Rozners,* E. Short Peptide Nucleic Acids Bind Strongly to Homopurine Tract of Double Helical RNA at pH 5.5. J. Am. Chem. Soc. 2010, 132, 8676-8681.
  27. Tanui, P.; Kullberg, M.; Song, N.; Chivate, Y.; Rozners,* E. Monomers for preparation of amide linked RNA: synthesis of C3'-homologated nucleoside amino acids from D-xylose. Tetrahedron 2010, 66, 4961-4964.
  28. Kolarovic, A.; Schweizer, E.; Greene, E.; Gironda, M.; Pallan, P. S.; Egli, M.; Rozners,* E. Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA. J. Am. Chem. Soc. 2009, 131, 14932-14937.
  29. Li, F.; Pallan, P.; Maier, M.; Rajeev, K.; Mathieu, S.; Kreutz, C.; Fan, Y.; Sanghvi, J.; Micura, R.; Rozners, E.; Manoharan, M.; Egli,* M. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme Nucleic Acids Res., 2007, 35, 6424-6438.
  30. Donahue, C. P.; Ni, J.; Rozners, E.; Glicksman, M.; Wolfe,* M. S. Identification of Tau Stem Loop RNA Stabilizers. J. Biomol. Screen. 2007, 12, 789 - 799.
  31. Rozners,* E.; Katkevica, D.; Strömberg, R. Oligoribonucleotide Analogues Having a Mixed Backbone of Phosphodiester and Formacetal Internucleoside Linkages with Vicinal 2'-O-Methyl Groups. ChemBioChem 2007, 8, 537-545 (Featured on Cover Page).
  32. Xu, Q.; Katkevica, D.; Rozners,* E. Toward Amide Modified RNA: Synthesis of 3'-Aminomethyl-5'-Carboxy-3',5'-Dideoxy Nucleosides. J. Org. Chem. 2006, 71, 5906-5913.
  33. Rozners,* E.; Smicius R.; Uchiyama, C. Expanding Functionality of RNA: Synthesis and Properties of RNA Containing Imidazole Modified Tandem G-U Wobble Base Pairs. Chem. Commun. 2005, 5778-5780.
  34. Rozners,* E.; Liu, Y. Monomers for Preparation of Amide Linked RNA: Asymmetric Synthesis of All Four Nucleoside 5'-Azido 3'-Carboxylic Acids. J. Org. Chem. 2005, 70, 9841-9848.
  35. Xu, Q.; Rozners,* E. Asymmetric Synthesis of trans-3,4-Dialkyl-γ-butyrolactones via an Acyl-Claisen and Iodolactonization Route. Org. Lett. 2005, 7, 2821-2824.
  36. Rozners,* E.; Fontanez, J. Enantioselective Nozaki-Hiyama Allylations Using a Multidentate Amino Alcohol as a Chiral Ligand. Lett. Org. Chem. 2005, 2, 407-409.
  37. Rozners,* E.; Moulder, J. Hydration of Short DNA, RNA, and 2'-OMe Oligonucleotides Determined By Osmotic Stressing. Nucleic Acids Res. 2004, 32, 248-254.
  38. Rozners,* E.; Xu, Q. Total Synthesis of 3',5'-C Branched Nucleosides. Org. Lett. 2003, 5, 3999-4001.
  39. Rozners,* E.; Katkevica, D.; Bizdena, E.; Strömberg, R. Synthesis and Properties of RNA Analogs Having Amides as Interuridine Linkages at Selected Positions J. Am. Chem. Soc. 2003, 125, 12125-12136.
  40. Rozners,* E.; Liu, Y. Toward Amide Linked RNA Mimics: Total Synthesis of 3'-C Branched Uridine Azido Acid via an Ene-Iodolactonization Approach. Org. Lett. 2003, 5, 181-184.
  41. Vedejs,* E.; Rozners, E. Parallel Kinetic Resolution Under Catalytic Conditions: A Three-Phase System Allows Selective Reagent Activation Using Two Catalysts. J. Am. Chem. Soc. 2001, 123, 2428-2429.
  42. Lindqvist, M.; Sarkar, M.; Winqvist, A.; Rozners, E.; Strömberg, R.; Gräslund,* A. Optical Spectroscopic Study of the Effects of a Single Deoxyribose Substitution in a Ribose Backbone: Implications in RNA-RNA Interaction. Biochemistry 2000, 39, 1693-1701.
  43. Sarkar, M.; Dornberger, U.; Rozners, E.; Fritzsche, H.; Strömberg, R.; Gräslund,* A. FTIR Spectroscopic Studies of Oligonucleotides That Model a Triple-Helical Domain in Self-Splicing Group I Introns. Biochemistry 1997, 36, 15463-15471.
  44. Rozners,* E.; Strömberg, R. Synthesis and Properties of Oligoribonucleotide Analogs Having Formacetal Internucleoside Linkages. J. Org. Chem. 1997, 62, 1846-1850.
  45. Sarkar, M.; Sigurdsson, S.; Tomac, S.; Sen, S.; Rozners, E.; Sjöberg, B. M.; Strömberg, R.; Gräslund,* A. A Synthetic Model for Triple-Helical Domains in Self-Splicing Group I Introns Studied by Ultraviolet and Circular Dichroism Spectroscopy. Biochemistry 1996, 35, 4678-4688.
  46. Rozners,* E.; Bizdena, E. Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides. Nucleosides and Nucleotides 1995, 14, 2009-2025.
  47. Rozners, E.; Westman, E.; Strömberg,* R. Evaluation of 2'-Hydroxyl Protection in RNA-Synthesis Using the H-Phosphonate Approach. Nucleic Acids Research 1994, 22, 94-99.
  48. Rozners,* E.; Renhofa, R.; Petrova, M.; Popelis, Y.; Kumpins, V.; Bizdena, E. Synthesis of Oligoribonucleotides by the H Phosphonate Approach Using Base-Labile 2'-O-Protecting Groups. V. Recent Progress in Development of the Method. Nucleosides and Nucleotides 1992, 11, 1579-1593.
  49. Rozners, E.; Renhof, R.; Cielens, I.; Kumpins, V.; Bizdena, E. Synthesis of Oligoribonucleotides by the H-Phosphonate Approach Using Base-Labile 2'-O-Protecting Groups. IV. A New Approach to Solve the Problem of Modification and Degradation of Oligoribonucleotides. Bioorg. Khim. 1992, 18, 263-271.
  50. Rozners, E.; Rekis, A.; Bizdena, E. Synthesis of Oligoribonucleotides by the H-Phosphonate Approach Using Base-Labile 2'-O-Protective Groups. III. Studies on Kinetics of 2'-3'-Migration of Aroyl Groups. Bioorg. Khim. 1992, 18, 107-111.
  51. Rozners, E.; Rekis, A.; Kumpins, V.; Bizdena, E. Synthesis of Oligoribonucleotides by the H-Phosphonate Method Using Base-Labile 2'-O-Protecting Groups. II. Some Aspects of Use of 2'-O-Benzoyl and Anisoyl Protecting Groups. Bioorg. Khim. 1990, 16, 1531-1536.
  52. Rozners, E.; Kumpins, V.; Rekis, A.; Bizdena, E. Solid-Phase Synthesis of Oligoribonucleotides by the H-Phosphonate Method Using 2'-O-Benzoyl Protective Group. Bioorg. Khim. 1988, 14, 1580-1582.

Invited Contributions and Reviews

  1. Rozners, E. RNA Metabolism and Drug Design In Encyclopedia of Molecular Cell Biology and Molecular Medicine, Meyers, R. A. (Editor), Wiley, 2015 (tentative), in press (Invited Review).
  2. Hnedzko, D.; Cheruiyot, S. K.; Rozners*, E. Using Triple Helix Forming Peptide Nucleic Acids for Sequence-selective Recognition of Double-stranded RNA Current Protocols in Nucleic Acid Chemistry, Chapter 4: Synthesis of Modified Oligonucleotides and Conjugates 2014, 4.60.1-4.60.23.
  3. Rozners, E. Sequence Selective Recognition of Double-Stranded RNA In Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, RNA Technologies. Erdmann, V.A.; Markiewicz W.T. and Barciszewski, J. (Editors), 2014, 167-180.
  4. Zengeya, T.; Gupta, P.; Rozners*, E. Sequence Selective Recognition of Double Stranded RNA using Triple Helix-forming Peptide Nucleic Acids In Peptide Nucleic Acids: Methods and Protocols (Methods in Molecular Biology), Peter E Nielsen, P. E. and Appella, D. H. (Editors), 2014, 1050, 83-94.
  5. Rozners, E. Recent Advances in Chemical Modification of Peptide Nucleic Acids Journal of Nucleic Acids, 2012, Article ID 518162, 8 pages, doi:10.1155/2012/518162 (Invited Review).
  6. Rozners, E. Sequence Selective Recognition of Biologically Relevant RNA Duplexes Biomolecules, 2012, 1, e102 (Invited Editorial).
  7. Rozners*, E. Determination of Nucleic Acid Hydration Using Osmotic Stress. Current Protocols in Nucleic Acid Chemistry, Chapter 7 Biophysical Analysis of Nucleic Acids. 2010, 7.14.1-7.14.13.
  8. Rozners*, E. Asymmetric De Novo Synthesis of Natural and Modified Carbohydrates and Nucleosides In Modern Approaches to the Synthesis of O- and N-Heterocycles; Kaufman, T. S., Ed.; Research Signpost, 2007; 129-148.
  9. Rozners*, E. Carbohydrate Chemistry for RNA Interference: Synthesis and Properties of RNA Analogues Modified in Sugar-Phosphate Backbone. Curr. Org. Chem. 2006, 10, 675-692.
  10. Rozners*, E. Synthesis, Properties and Applications of Backbone Modified RNA Analogues In Recent Developments in Nucleic Acids Research. Vol 2. Transworld Research Network, 2006; 15-38.
  11. Rozners*, E. Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function. Lett. Org. Chem. 2005, 2, 398-403 (Invited Highlight).
  12. Vedejs*, E.; Daugulis, O.; MacKay, J. A.; Rozners, E. Enantioselective Acyl Transfer Using Chiral Phosphine Catalysts. Synlett 2001, 1499-1505.

Patent Applications

  1. Rozners, E.; Zengeya, T. Compositions and methods for recognition of RNA using triple helical peptide nucleic acids U.S. Pat. Appl. Publ. (2014), US 20140206838 A1 20140724.

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© Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000


Updated 09/20/2017
By Monika Roznere
Photos: Jonathan Cohen and group members