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Group News

August 21, 2017

Paper published: Daniel and Samwel in collaboration with Dharmacon, Vandebilt and Rochester researchers have published a paper Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs in Nucleic Acids Research. Congrats Daniel and Samwel!


August 1, 2017

NSF grant application funded: Our group has been awarded a grant totaling $502K from the National Science Foundation to work on a collaborative research project: Nucleobase-Modified Peptide Nucleic Acid (PNA) for Sequence Selective Triple-Helical Recognition of Non-Coding Ribonucleic Acid (RNA). The project is a partnership with Dr. James A. MacKay who received a complementary award totaling $196K from the National Science Foundation to support related activities with undergraduates at Elizabethtown College.


July 21, 2017

Paper published: Venu has published a paper Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3'-Homologated Nucleoside Amino Acids in Organic Letters. Congrats Venu!


May 19, 2017

Congratulations Diana and Samwel on successful defense of PhD thesis and graduation!


December 17, 2016

Paper published: In collaboration with Dennis McGee (Biology) Diana and Yannis have published a paper Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids in RNA journal. Congrats Diana and Yannis!


December 1, 2016

Paper published: In collaboration with colleagues from FIBER, Konan University in Kobe, Japan, Diana has co-authored a paper Triplex-forming PNA modified with unnatural nucleobases: the role of protonation entropy in RNA binding in Physical Chemistry Chemical Physics. Congrats Diana!


November 23, 2016

Eriks receives 2016 Chancellors award for Scholarship and Creative Activities.

Read more in Binghamton University's Inside magazine.

September 3, 2016

Paper published: In collaboration with Dennis McGee (Biology) Diana has published a paper Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye in Bioorganic and Medicinal Chemistry. Congrats Diana!


August 17, 2016

Paper published: Samwel has published a paper Fluorescent 2-Aminopyridine Nucleobases for Triplex-Forming Peptide Nucleic Acids in ChemBioChem. Congrats Samwel!


July 26, 2016

Eriks delivered an invited talk Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids for Sequence-Selective Recognition of Double-Stranded RNA at the 2016 Telluride Workshop on Nucleic Acid Chemistry in Telluride, CO.


July 6, 2016

Eriks delivered an invited talk Sequence-Selective Recognition of Double-Stranded RNA and Enhanced Cellular Uptake of Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids at the FIBER International Summit for Nucleic Acids in Kobe, Japan.


June 24, 2016

Brulinda and Ervin presented posters at the annual NIH Bridges to the Baccalaureate Program closing meeting.


June 16, 2016

Paper published: In collaboration with colleagues from FIBER, Konan University in Kobe, Japan, Diana has co-authored a paper Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing in Chemical Communications. The paper was featured on the Back Cover Image of June 28 issue of Chemical Communications. Congrats Diana!


March 18, 2016

Diana and Yanni presented posters at the 3nd Annual Symposium on RNA Science held by The RNA Institute, University at Albany.


January 12, 2016

Paper published: In collaboration with colleagues from FIBER, Konan University in Kobe, Japan, Diana has co-authored a paper Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells in Angewandte Chemie. The paper was selected as the Front Cover Image of January 18 issue of Angewandte Chemie. Congrats Diana!

 

May 27, 2015

Samwel received the Outstanding Graduate Teaching Assistant Award. Congrats Samwel!


March 20, 2015

Diana and Samwel presented posters at the 2nd Annual Symposium on RNA Science held by The RNA Institute, University at Albany.


March 18, 2015

Samwel received the Binghamton University Graduate Student Award for Excellence in Teaching. Congrats Samwel!


January 13, 2015

Eriks delivered an invited talk Sequence-Selective Recognition of Double-Stranded RNA Using Cationic Peptide Nucleic Acids at the IUPAC 10th International Symposium on Bio-Organic Chemistry in Pune, India.


August 1, 2014

Funding Success: Our group has received an NSF research award (CHE 1406433, $414,637 for three years) to continue the project on triple helical recognition of double-stranded RNA by peptide nucleic acids. The goal of this project is to develop new methods for molecular recognition of and functional interference with biologically relevant double-stranded RNA. The project involves collaboration with structural biochemists at University at Albany. In a long term, the project may open the door to new ways for targeting double-stranded RNA in live cells, which has been a long-standing fundamental problem and practical limitation in RNA biochemistry.


June 19, 2014

Eriks delivered an invited talk Sequence-Selective Recognition of Double-Stranded RNA Using Triple Helix Forming Peptide Nucleic Acids at the Nucleic Acid Research & Development Conference in San Diego.


May 9, 2014

Paper published: In collaboration with colleagues from Thermo Fisher and Vanderbilt University our group has published a paper Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs in Nucleic Acids Research. The paper reports an intriguing finding that amide-modified siRNAs may be more active than the native ones. Congrats Daniel and Selvam!


April 1, 2014

Funding Success: Our group has received an NIH award (R01 GM071461, ~$1,5 million for four years) to continue research on the recently discovered biological activity of amide-modified RNA. The goal of this project is to create novel research tools and compounds for therapeutic applications of modified short interfering RNAs, while looking for new fundamental insights into structure and function of RNA. The project involves collaboration with structural biochemists at Vanderbilt University and University of Rochester and RNA biologists at Dharmacon (GE Life Sciences). In a long term, the project may open the door for development of new drugs for diseases where the traditional pharmaceutics have been less successful.


January 7, 2014

Paper published: In collaboration with colleagues from Thermo Fisher and University of Rochester our group has published a paper Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages in Organic & Biomolecular Chemistry. Congrats Paul!


November 13-15, 2013

Eriks delivered a plenary talk on molecular recognition of double-stranded RNA using chemically modified PNA at the 40th International Symposium of Nucleic Acid Chemistry (ISNAC2013) at Kanagawa University in Yokohama, Japan. As part of the weeklong lecture tour, Prof. Rozners also delivered invited talks on amide-modified RNA at Konan University in Kobe and Gunma University in Kiryu.


October 8, 2013

Paper published: Thomas and Artem have published a paper Improvement of sequence selectivity in triple helical recognition of RNA by phenylalanine-derived PNA in Artificial DNA, PNA & XNA. Congrats Thomas and Artem!


May 30, 2013

Paper published: In collaboration with Christof Grewer (Chemistry) and Dennis McGee (Biology) our group has published a paper Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates in ACS Chemical Biology. Congrats Toyosi, Thomas and Diana!


November 4, 2012

Paper published: A research communication by Thomas and Pankaj was published in Angewandte Chemie and highlighted as a Very Important Paper (VIP). Only a small number of papers, which receive the highest evaluation from all of the reviewers, are designated as VIP in Angewandte Chemie. The paper describes a discovery made by our group that 2-aminopyridine modified PNAs form exceptionally stable and sequence selective complexes with double-stranded RNA. The modified PNA displays unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences. Thus, PNA may have unique and previously underappreciated potential for recognition of biologically relevant RNAs. Congrats Thomas and Pankaj!

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© Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000


Updated 09/20/2017
By Monika Roznere
Photos: Jonathan Cohen and group members