Binghamton University Department of Chemistry
May 8, 2024
Ilze receives Fellowship: Ilze receives Provost Dissertation Fellowship. Congrats Ilze!
March 20, 2024
Invited Lecture: Eriks delivered an invited talk "Amide-Modified Oligonucleotides for Chemical Control of Functional RNAs" at Oligonucleotide & Peptide Therapeutics Conference (TIDES Asia), Kyoto, Japan
March 11, 2024
Invited Lecture: Eriks delivered an invited talk "Sequence Selective Recognition of Double-Stranded RNA by Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids" at Nihon University, Tokyo, Japan
February 29, 2024
Invited Lecture: Eriks delivered an invited talk "Amide-Modified RNA: Using Protein Backbone to Modulate Function of RNA" at Special FIBER International Summit for Nucleic Acids (S-FISNA), Konan University, Kobe, Japan
February 5, 2024
Paper published: Chandan and Michael published a paper
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage
in ACS Chemical Biology. Congrats Chandan and Michael!
For more information...
February 3, 2024
Paper published: Ilze and Mohammed published an invited paper
Comparison of 2-Aminopyridine and 4-Thiopseudisocytosine PNA Nucleobases for Hoogsteen Recognition of Guanosine in RNA
in ACS Omega. Congrats Ilze and Mohammed!
For more information...
January 22, 2024
New Project funded! Our group has renewed the Maximizing Investigators' Research Award (MIRA R35 GM130207, $2,109,000 for 5 years) from the
National Institute of General Medical Sciences (NIGMS) to support our entire research portfolio on Chemical Approaches
to Control the Function of Regulatory RNAs.
January 12, 2024
Paper published: Martins (Latvian Institute of Organic Synthesis), James (Elizabethtown College) and Eriks published a Feature Article
Triplex-forming peptide nucleic acids as emerging ligands to modulate structure and function of complex RNAs
in Chemical Communications.
For more information...
November 17, 2023
Paper published: Our group in collaboration with colleagues from Elizabethtown College and Latvian Institute of Organic Synthesis, published an invited paper
Synthesis of 2-Aminopyridine-Modified Peptide Nucleic Acids
in Synlett. Congrats Ilze, Brandon, Sara, and Chris!
For more information...
October 19, 2023
Invited Lecture: Eriks delivered an invited talk "Amide-Modified Oligonucleotides for Chemical Control of Functional RNAs" at Advances in Noncanonical Nucleic Acids, (ANNA 2023) Maribor, Slovenia
August 30, 2023
Paper published: Brandon, in collaboration with colleagues from Elizabethtown College and Latvian Institute of Organic Synthesis, published a paper
Improved Triplex-Forming Isoorotamide PNA Nucleobases for A-U Recognition of RNA Duplexes
in Chemistry – A European Journal. Congrats Brandon!
For more information...
July 24, 2023
Invited Lecture: Eriks delivered an invited talk "Sequence Selective Recognition of Double-Stranded RNA by Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids" at Tohoku University, Sendai, Japan
June 25-30, 2023
Conference particiation: Ilze, Michael, Sara, Brandon, Jayamini, and Motiar presented posters at the Nucleosides, Nucleotides and Oligonucleotides Gordon Research Conference in Newport. Sara and Brandon won the Best Poster Awards. Congrats Sara and Brandon!
June 15, 2023
Paper published: Ilze, in collaboration with colleagues from Latvian Institute of Organic Synthesis, published a paper
Nucleobase and Linker Modification for Triple-Helical Recognition of Pyrimidines in RNA Using Peptide Nucleic Acids
in ChemBioChem. Congrats Ilze!
For more information...
May 10, 2023
Chris graduates with PhD: Chris defended his thesis and graduated with PhD degree from Binghamton University. Congrats Chris!
May 8, 2023
Paper published: Chris, Motiar and Vipin published a paper
Triplex-Forming Peptide Nucleic Acid Controls Dynamic Conformations of RNA Bulges
in Journal of the American Chemical Society. Congrats Chris, Motiar and Vipin!
For more information...
March 22, 2023
Chris receives Graduate Student Excellence Award: Chris received the 2023 Binghamton University Graduate Student Award for Excellence in Research. Congrats Chris!
March 9, 2023
Invited Lecture: Eriks delivered an invited talk "Amide-Modified Oligonucleotides for Chemical Control of Functional RNAs" at Eli Lilly and Company
December 29, 2022
Paper published: Michael, Julien, Venu, Praveen, Lamorna and Chandan published a paper
Amide Modifications in the Seed Region of the Guide Strand Improve the On-Target Specificity of Short Interfering RNA
in ACS Chemical Biology. Congrats Michael, Julien, Venu, Praveen, Lamorna and Chandan!
For more information...
May 31, 2022
Paper published: Chris, in collaboration with colleagues from Latvian Institute of Organic Synthesis, published a paper
Extended 2-Guanidyl Pyridine PNA Nucleobase for Triple-Helical Hoogsteen Recognition of Cytosine in Double Stranded RNA
in Chemical Communications. Congrats Chris!
For more information...
May 31, 2022
Paper published: Julien and Chandan published a paper
Optimization of Automated Synthesis of Amide-Linked RNA
in ACS Omega. Congrats Julien and Chandan!
For more information...
February 28, 2022
Paper published: Venu, Praveen and Lamorna published a paper
Amide Internucleoside Linkages Are Well Tolerated in Protospacer Adjacent Motif-Distal Region of CRISPR RNAs
in ACS Chemical Biology. Congrats Venu, Praveen and Lamorna!
For more information...
December 16, 2021
Paper published: Nikita and Ilze published a paper
Cellular uptake of 2-aminopyridine-modified peptide nucleic acids conjugated with cell-penetrating peptides
in Biopolymers. Congrats Nikita and Ilze!
For more information...
November 1, 2021
New Project funded! Our group has received an R21 award from NIAID "Targeting SARS-CoV-2 RNA Pseudoknots Using Triplex-Forming Peptide Nucleic Acids".
For more information...
August 25, 2021
Eriks receives ACS Award: Eriks received the 2021 Melville L. Wolfrom Award from the Division of Carbohydrate Chemistry at the American Chemical Society National Meeting in Atlanta. The Award recognizes individuals who have provided outstanding service to the Division of Carbohydrate Chemistry and the field of carbohydrate chemistry.
June 11, 2021
Paper published: Nikita and Diana, in collaboration with colleagues from FIBER, Konan University in Japan, published a paper
Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197
in ACS Chemical Biology. Congrats Nikita and Diana!
For more information...
June 7, 2021
Paper published: Chris, Nikita and Justin published a paper
The 2-Aminopyridine Nucleobase Improves Triple-Helical Recognition of RNA and DNA When Used Instead of Pseudoisocytosine in Peptide Nucleic Acids
in Biochemistry. Congrats Chris, Nikita and Justin!
For more information...
May 13, 2021
PhD Graduation: Congratulations Nikita and Julien on receiving PhD degrees! Best of luck in your future endeavors!
April 21, 2021
Paper published: Nikita and Justin, in collaboration with colleagues from Latvian Institute of Organic Synthesis, published a paper
Pyridazine Nucleobase in Triplex-Forming PNA Improves Recognition of Cytosine Interruptions of Polypurine Tracts in RNA
in ACS Chemical Biology. Congrats Nikita and Justin!
For more information...
January 13, 2021
Paper published: Nikita, in collaboration with colleagues from Elizabethtown College and Latvian Institute of Organic Synthesis, published a paper
Extended Peptide Nucleic Acid Nucleobases Based on Isoorotic Acid for the Recognition of A–U Base Pairs in Double-Stranded RNA
in Chemistry - A European Journal. Congrats Nikita!
For more information...
October 28, 2020
Paper published: Chris published a paper
Impact of Chirality and Position of Lysine Conjugation in Triplex-Forming Peptide Nucleic Acids
in ACS Omega. Congrats Chris!
For more information...
August 10, 2020
Eriks wins ACS Award: Eriks has been selected to receive the 2021 Melville L. Wolfrom Award from the Division of Carbohydrate Chemistry, American Chemical Society. The Award recognizes individuals who have provided outstanding service to the Division of Carbohydrate Chemistry and the field of carbohydrate chemistry.
July 22, 2020
Paper published: Vipin and Nikita published a paper
Triplex‐Forming Peptide Nucleic Acids with Extended Backbones
in ChemBioChem. Congrats Vipin and Nikita!
For more information...
July 13, 2020
Paper published: Venu and Eriks published a paper
Amide-Modified RNA: Using Protein Backbone to Modulate Function of Short Interfering RNAs
in Accounts of Chemical Research. Their Account was featured as a Cover Picture of the September issue of the Journal.
For more information...
November 20, 2019
Paper published: Venu and Julien published a paper
Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages
in Chemistry - A European Journal. Congrats Venu and Julien!
For more information...
October 14, 2019
Eriks delivered an invited talk Sequence Selective Recognition of Double-Stranded RNA by Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids
at the 15th Annual Meeting of the Oligonucleotide Therapeutics Society in Munich, Germany.
September 20, 2019
Paper published: Nikita, in collaboration with colleagues from Latvian Institute of Organic Synthesis, Elizabethtown College and University of Rochester, published a paper
Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids
in Journal of Organic Chemistry. Congrats Nikita!
For more information...
June 23-27, 2019
The group attended Nucleosides, Nucleotides and Oligonucleotides Gordon Research Conference at Salve Regina University, Newport RI.
Venu, Julien, Nikita and Chris presented posters.
Eriks delivered an invited talk Amide-Modified RNA: Synthesis, Structure And RNA Interference Activity
February 11, 2019
Paper published: Venu in collaboration with colleagues from University of Rochester and Elizabethtown College, published a paper
Synthetic, Structural, and RNA Binding Studies on 2‐Aminopyridine‐Modified Triplex‐Forming Peptide Nucleic Acids
in Chemistry - A European Journal. Congrats Venu!
For more information...
February 1, 2019
Our group has received a Maximizing Investigators' Research Award (MIRA R35 GM130207, $2,040,290 for 5 years) from the
National Institute of General Medical Sciences (NIGMS) to support our entire research portfolio on Chemical Approaches
to Control the Function of Regulatory RNAs.
August 27-30, 2018
Congratulations Venu on the 1st Place Poster Award in the Postdoc Category at the XXIII International Roundtable
on Nucleosides, Nucleotides & Nucleic Acids UC San Diego, La Jolla, California. Julien and Nikita also
presented posters at this meeting.
January 3, 2018
Paper published: Irina, Venu, Daniel and Samwel in collaboration with Dharmacon, Vandebilt and
Rochester researchers have published a paper A Single Amide Linkage in the Passenger Strand Suppresses
Its Activity and Enhances Guide Strand Targeting of siRNAs
in ACS Chemical Biology. Congrats Irina,
Venu, Daniel and Samwel!
For more information...
September 27, 2017
Paper published: In collaboration with Scott Kennedy (University of Rochester) Irina has published a
paper 2-Methoxypyridine as a Thymidine Mimic in Watson--Crick Base Pairs of DNA and PNA: Synthesis,
Thermal Stability, and NMR Structural Studies
in ChemBioChem. Congrats Irina!
For more information...
August 21, 2017
Paper published: Daniel and Samwel in collaboration with Dharmacon, Vandebilt and Rochester researchers
have published a paper Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated
in the guide strand of short interfering RNAs
in Nucleic Acids Research. Congrats Daniel and Samwel!
For more information...
August 1, 2017
NSF grant application funded: Our group has been awarded a grant totaling $502K from the National Science
Foundation to work on a collaborative research project: Nucleobase-Modified Peptide Nucleic Acid (PNA) for
Sequence Selective Triple-Helical Recognition of Non-Coding Ribonucleic Acid (RNA). The project is a partnership
with Dr. James A. MacKay who received a complementary award totaling $196K from the National Science Foundation to
support related activities with undergraduates at Elizabethtown College.
For more information...
July 21, 2017
Paper published: Venu has published a paper Concurrent Hydrogenation of Three Functional Groups Enables
Synthesis of C3'-Homologated Nucleoside Amino Acids
in Organic Letters. Congrats Venu!
For more information...
May 19, 2017
Congratulations Diana and Samwel on successful defense of PhD thesis and graduation!
December 17, 2016
Paper published: In collaboration with Dennis McGee (Biology) Diana and Yannis have published a
paper Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic
nucleobase and backbone-modified peptide nucleic acids
in RNA journal. Congrats Diana and Yannis!
For more information...
December 1, 2016
Paper published: In collaboration with colleagues from FIBER, Konan University in Kobe, Japan,
Diana has co-authored a paper Triplex-forming PNA modified with unnatural nucleobases: the role of
protonation entropy in RNA binding
in Physical Chemistry Chemical Physics. Congrats Diana!
For more information...
November 23, 2016
Eriks receives 2016 Chancellors award for Scholarship and Creative Activities.
Read more in Binghamton University's Inside magazine.
September 3, 2016
Paper published: In collaboration with Dennis McGee (Biology) Diana has published a paper Synthesis
and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye
in Bioorganic and Medicinal Chemistry. Congrats Diana!
For more information...
August 17, 2016
Paper published: Samwel has published a paper Fluorescent 2-Aminopyridine Nucleobases for Triplex-Forming Peptide Nucleic
Acids
in ChemBioChem. Congrats Samwel!
For more information...
July 26, 2016
Eriks delivered an invited talk Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids for
Sequence-Selective Recognition of Double-Stranded RNA
at the 2016 Telluride Workshop on Nucleic Acid
Chemistry in Telluride, CO.
July 6, 2016
Eriks delivered an invited talk Sequence-Selective Recognition of Double-Stranded
RNA and Enhanced Cellular Uptake of Cationic Nucleobase and Backbone-Modified
Peptide Nucleic Acids
at the FIBER International Summit for Nucleic Acids in Kobe, Japan.
June 24, 2016
Brulinda and Ervin presented posters at the annual NIH Bridges to the Baccalaureate Program
closing meeting.
June 16, 2016
Paper published: In collaboration with colleagues from FIBER, Konan University in Kobe,
Japan, Diana has co-authored a paper Triplex-forming peptide nucleic acid modified with
2-aminopyridine as a new tool for detection of A-to-I editing
in Chemical Communications.
The paper was featured on the Back Cover Image of June 28 issue of Chemical Communications.
Congrats Diana!
For more information...
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© Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000
Updated 09/20/2017
By Monika Roznere
Photos: Jonathan Cohen and group members