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Selected Recent Publications

1: Dong Y, Wang J, Garibsingh RA, Hutchinson K, Shi Y, Eisenberg G, Yu X, Schlessinger A, Grewer C. Conserved allosteric inhibition mechanism in SLC1 transporters. Elife. 2023 Mar 1;12:e83464. doi: 10.7554/eLife.83464. PMID: 36856089; PMCID: PMC10017108.

2: Ndaru E, Zielewicz L, Shi Y, Hutchinson K, Garibsingh RA, Schlessinger A, Grewer C. Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters. J Phys Org Chem. 2022 Nov;35(11):e4347. doi: 10.1002/poc.4347. Epub 2022 Mar 21. PMID: 36568026; PMCID: PMC9786560.

3: Wang J, Dong Y, Grewer C. Functional and Kinetic Comparison of Alanine Cysteine Serine Transporters ASCT1 and ASCT2. Biomolecules. 2022 Jan 11;12(1):113. doi: 10.3390/biom12010113. PMID: 35053261; PMCID: PMC8773628.

4: Shi Y, Wang J, Ndaru E, Grewer C. Pre-steady-state Kinetic Analysis of Amino Acid Transporter SLC6A14 Reveals Rapid Turnover Rate and Substrate Translocation. Front Physiol. 2021 Nov 16;12:777050. doi: 10.3389/fphys.2021.777050. PMID: 34867484; PMCID: PMC8637194.

5: Grewer C. Special Issue in Honor of Baruch Kanner. Neurochem Res. 2022 Jan;47(1):1-2. doi: 10.1007/s11064-021-03458-z. PMID: 34617187.

6: Garibsingh RA, Ndaru E, Garaeva AA, Shi Y, Zielewicz L, Zakrepine P, Bonomi M, Slotboom DJ, Paulino C, Grewer C, Schlessinger A. Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2104093118. doi: 10.1073/pnas.2104093118. PMID: 34507995; PMCID: PMC8449414.

7: Wang J, Li P, Yu X, Grewer C. Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters. PLoS One. 2021 Apr 23;16(4):e0250635. doi: 10.1371/journal.pone.0250635. PMID: 33891665; PMCID: PMC8064580.

8: Wang J, Zielewicz L, Dong Y, Grewer C. Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain. Neurochem Res. 2022 Jan;47(1):148-162. doi: 10.1007/s11064-021-03247-8. Epub 2021 Feb 6. PMID: 33550531; PMCID: PMC9512041.

9: Wang J, Zhang K, Goyal P, Grewer C. Mechanism and potential sites of potassium interaction with glutamate transporters. J Gen Physiol. 2020 Oct 5;152(10):e202012577. doi: 10.1085/jgp.202012577. PMID: 32835376; PMCID: PMC7537348.

10: Ndaru E, Garibsingh RA, Zielewicz L, Schlessinger A, Grewer C. Interaction of the neutral amino acid transporter ASCT2 with basic amino acids. Biochem J. 2020 Apr 30;477(8):1443-1457. doi: 10.1042/BCJ20190859. PMID: 32242892; PMCID: PMC9535927.

For a list of all publications from the Grewer lab please click the following link: Grewer Lab